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Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring

5 Oct 2010

Abstract excerpt

Molecular mechanisms predisposing people to insulin resistance are starting to emerge. Altered insulin signaling for hepatic gluconeogenesis and muscle glucose uptake is thought to play a central role. Development under suboptimal conditions is also known to increase the risk of insulin resistance in adulthood. However, the partial contributions of reduced oxygen vs. nutrient delivery to the fetus, two common...

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Birth, Development, and Health
Gestational Diabetes Research and Management
Pregnancy and preeclampsia studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20923964
DOI: 10.1096/fj.10-158188

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