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Article

Aromatic-aromatic interactions and protein stability. Investigation by double-mutant cycles.

Journal of molecular biology - 20 Mar 1991

Serrano L, Bycroft M, Fersht A R

Abstract excerpt

The side-chains of phenylalanine and tyrosine residues in proteins are frequently found to be involved in pairwise interactions. These occur both within repeating elements of secondary structure and in tertiary and quaternary interactions. It has been suggested that they are important in protein folding and stability, and non-bonded potential energy calculations indicate that a typical aromatic-aromatic...

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Identifiers

PMID: 2010920
DOI: 10.1016/0022-2836(91)90725-l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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