Safety and immunogenicity of live attenuated cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in infants and children.

doi:10.1093/infdis/163.4.740

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Article

Safety and immunogenicity of live attenuated cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in infants and children.

The Journal of infectious diseases - 1 Apr 1991

Edwards K M, King J C, Steinhoff M C, Thompson J, Clements M L, Wright P F, Murphy B R

Abstract excerpt

A cold-adapted (ca) influenza B reassortant vaccine consisting of two genes encoding the hemagglutinin and neuraminidase from wild-type influenza B/Ann Arbor/1/86 virus and the six internal RNA segments from influenza B/Ann Arbor/1/66 ca virus was evaluated in 18 seropositive and 57 seronegative infants and children. The ca reassortant was infectious in seronegative vaccinees, with an estimated 50% human...

Topics

Antibodies, Viral
Child
Child, Preschool
Cold Temperature
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Hemagglutination Inhibition Tests
Humans
Infant
Influenza B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza Vaccines

Kinetics

Nasal Mucosa

Phenotype

Vaccines, Attenuated

Vaccines, Synthetic

Source

Open in PubMed

Identifiers

PMID: 2010627
DOI: 10.1093/infdis/163.4.740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2010627-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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