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Article

No evidence for prion protein gene locus multiplication in Creutzfeldt-Jakob disease.

Neuroscience letters - 12 Mar 2010

Collins Steven J, Schuur Maaike, Boyd Alison, Lewis Victoria, Klug Genevieve M, McGlade Amelia, van Oosterhout Andrew, Breedveld Guido, Oostra Ben A, Masters Colin, Van Duijn Cornelia M

Abstract excerpt

Precedent of causative multiplication of key gene loci exists in familial forms of both Alzheimer's and Parkinson's diseases. Genetic Creutzfeldt-Jakob disease (CJD) is often clinically indistinguishable from sporadic disease and inexplicably, a negative family history of a similar disorder occur...

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Source

Identifiers

PMID: 20105449
DOI: 10.1016/j.neulet.2010.01.043

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20105449-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence for prion protein gene locus multiplication in Creutzfeldt-Jakob disease.PMID 20105449Read ↗

Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene.Semantic proximity Read ↗

Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.Semantic proximity Read ↗

Report about four novel mutations in the prion protein gene.Semantic proximity Read ↗

Genetic epidemiology of Creutzfeldt-Jakob disease in Europe.Semantic proximity Read ↗

A French cluster of Creutzfeldt-Jakob disease: a molecular analysis.Semantic proximity Read ↗

Neuropathologically directed profiling of PRNP somatic and germline variants in sporadic human prion disease.Semantic proximity Read ↗

A case of sporadic Creutzfeldt-Jakob disease with a Gerstmann-Sträussler-Scheinker phenotype but no alterations in the PRNP gene.Semantic proximity Read ↗

Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion.Semantic proximity Read ↗

Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene.Semantic proximity Read ↗

Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study.Semantic proximity Read ↗

Inherited mtDNA variations are not strong risk factors in human prion disease.Semantic proximity Read ↗

The molecular genetics of familial Creutzfeldt-Jakob disease in France.Semantic proximity Read ↗

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