Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study.

BMC medical genetics - 7 Apr 2016

Balendra Rubika, Uphill James, Collinson Claire, Druyeh Ronald, Adamson Gary, Hummerich Holger, Zerr Inga, Gambetti Pierluigi, Collinge John, Mead Simon

Abstract excerpt

BACKGROUND: Human prion diseases are relentlessly progressive neurodegenerative disorders which include sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). Aside from variants of the prion protein gene (PRNP) replicated association at genome-wide levels of significance has proven elusive. A recent association study identified variants in or near to the PLCXD3 gene locus as strong disease risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creutzfeldt-Jakob Syndrome
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Germany

Share to Phosphoinositide Phospholipase C

Share to Prion Proteins

Share to Prions

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 27055460
DOI: 10.1186/s12881-016-0278-2
PMCID: PMC4823897

Genes

PLCXD3
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study.PMID 27055460Read ↗

Splice site SNPs of phospholipase PLCXD3 are significantly associated with variant and sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.Semantic proximity Read ↗

Genome-wide association study identifies risk variants for sporadic Creutzfeldt-Jakob disease in <i>STX6</i> and <i>GAL3ST1</i>Semantic proximity Read ↗

Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.Semantic proximity Read ↗

Rare structural genetic variation in human prion diseases.Semantic proximity Read ↗

Neuropathologically directed profiling of PRNP somatic and germline variants in sporadic human prion disease.Semantic proximity Read ↗

Genome wide association studies and prion disease.Semantic proximity Read ↗

Neuropathologically-directed profiling of <i>PRNP</i> somatic and germline variants in sporadic human prion diseaseSemantic proximity Read ↗

Estimation of the number of inherited prion disease mutation carriers in the UK.Semantic proximity Read ↗

Genome wide association study of clinical duration and age at onset of sporadic CJDSemantic proximity Read ↗

Genetic risk factors for Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.