Article
A case of sporadic Creutzfeldt-Jakob disease with a Gerstmann-Sträussler-Scheinker phenotype but no alterations in the PRNP gene.
Acta neuropathologica - 1 Oct 1998
Liberski P P, Barcikowska M, Cervenakova L, Bratosiewicz J, Marczewska M, Brown P, Gajdusek D C
Abstract excerpt
We report here an unusual sporadic case of Creutzfeldt-Jakob disease (CJD) characterized by an abundance of prion protein (PrP)-immunopositive kuru and multicentric but not florid plaques. Molecular genetic analysis of the PRNP open reading frame region spanning codons 8-221 was performed. Neithe...
Topics
- Amyloid
- Creutzfeldt-Jakob Syndrome
- Gerstmann-Straussler-Scheinker Disease
- Heterozygote
- Humans
- Male
- Microscopy, Electron
- Middle Aged
- Molecular Biology
- Open Reading Frames
- Phenotype
- Prion Proteins
- Prions
- Protein Precursors