Article
The molecular genetics of familial Creutzfeldt-Jakob disease in France.
Journal of the neurological sciences - 1 Oct 1991
Brown P, Goldfarb L G, Cathala F, Vrbovská A, Sulima M, Nieto A, Gibbs C J, Gajdusek D C
Abstract excerpt
Five French families with Creutzfeldt-Jakob disease (CJD) were found to have either of 2 different point mutations (at codons 178 and 200) in the amyloid precursor gene (PRNP) on chromosome 20. The ancestry of these and other CJD families outside of France suggests that the codon 178 mutation had a northern European origin, while the codon 200 mutation originated in central Europe and the Mediterranean basin....
Topics
- Amyloid beta-Protein Precursor
- Chromosomes, Human, Pair 20
- Codon
- Creutzfeldt-Jakob Syndrome
- DNA
- Electroencephalography
- Female
- France
- Humans
- Male
- Middle Aged