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Article

Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1991

Goldfarb L G, Brown P, McCombie W R, Goldgaber D, Swergold G D, Wills P R, Cervenakova L, Baron H, Gibbs C J, Gajdusek D C

Abstract excerpt

The PRNP gene, encoding the amyloid precursor protein that is centrally involved in Creutzfeldt-Jakob disease (CJD), has an unstable region of five variant tandem octapeptide coding repeats between codons 51 and 91. We screened a total of 535 individuals for the presence of extra repeats in this region, including patients with sporadic and familial forms of spongiform encephalopathy, members of their families,...

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Identifiers

PMID: 1683708
DOI: 10.1073/pnas.88.23.10926
PMCID: PMC53045

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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