Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of viral quasispecies in interferon-treated patients with chronic hepatitis C virus infection.

Journal of hepatology - 1 Oct 1999

Hassoba H M, Bzowej N, Berenguer M, Kim M, Zhou S, Phung Y, Grant R, Pessoa M G, Wright T L

Abstract excerpt

BACKGROUND/AIMS: To evaluate whether interferon treatment failure/relapse is related to changes in hepatitis C virus quasispecies complexity (number of variants) or diversity (genetic relatedness of variants). METHODS: We analyzed hypervariable region heterogeneity in hepatitis C virus-infected patients by heteroduplex mobility assay and by phylogenetic analysis of sequenced clones. Sera from 11 patients were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Heteroduplex Analysis

Share to Interferons

Share to Reference Values

Source

Identifiers

PMID: 10551384
DOI: 10.1016/s0168-8278(99)80340-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of viral quasispecies in interferon-treated patients with chronic hepatitis C virus infection.PMID 10551384Read ↗

Dynamics of hepatitis C virus NS5A quasispecies during interferon and ribavirin therapy in responder and non-responder patients with genotype 1b chronic hepatitis C.Semantic proximity Read ↗

Correlation between pre-treatment quasispecies complexity and treatment outcome in chronic HCV genotype 3a.Semantic proximity Read ↗

Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens.Semantic proximity Read ↗

Hepatitis C virus quasispecies and response to interferon therapy in patients with chronic hepatitis C: a prospective study.Semantic proximity Read ↗

Hepatitis C virus E2 and NS5A region variability during sequential treatment with two interferon-alpha preparations.Semantic proximity Read ↗

Assessment of hepatitis C virus quasispecies heterogeneity by gel shift analysis: correlation with response to interferon therapy.Semantic proximity Read ↗

Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcomeSemantic proximity Read ↗

Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infection.Semantic proximity Read ↗

HVR-1 quasispecies modifications occur early and are correlated to initial but not sustained response in HCV-infected patients treated with pegylated- or standard-interferon and ribavirin.Semantic proximity Read ↗

Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C.Semantic proximity Read ↗

The clinical significance of changes in genetic heterogeneity of the hypervariable region 1 in chronic hepatitis C with interferon therapy.Semantic proximity Read ↗

Effect of increasing dose of interferon on the evolution of hepatitis C virus 1b quasispecies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.