Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the cancer kinome through polypharmacology.

Nature reviews. Cancer - 1 Feb 2010

Knight Zachary A, Lin Henry, Shokat Kevan M

Abstract excerpt

Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strategi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Antineoplastic Combined Chemotherapy Protocols
Share to Drug Delivery Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Discovery

Share to Drug Resistance, Neoplasm

Share to Protein Kinase Inhibitors

Share to Protein Kinases

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 20094047
DOI: 10.1038/nrc2787
PMCID: PMC2880454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20094047-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the cancer kinome through polypharmacology.PMID 20094047Read ↗

Kinase Inhibitors in Multitargeted Cancer TherapySemantic proximity Read ↗

Targeting the Human Kinome for Cancer Therapy: Current PerspectivesSemantic proximity Read ↗

Targeted Therapies in Cancer: To Be or Not to Be, SelectiveSemantic proximity Read ↗

Polypharmacology is an enduring and nearly universal property of kinase inhibitorsSemantic proximity Read ↗

Kinase-targeted cancer therapies: progress, challenges and future directionsSemantic proximity Read ↗

Recent advances in targeting protein kinases and pseudokinases in cancer biologySemantic proximity Read ↗

Challenges and Opportunities in Defining the Essential Cancer KinomeSemantic proximity Read ↗

Kinase Inhibitors and Kinase-Targeted Cancer Therapies: Recent Advances and Future PerspectivesSemantic proximity Read ↗

The molecular basis of targeting protein kinases in cancer therapeutics.Semantic proximity Read ↗

Rational therapeutic intervention in cancer: kinases as drug targets.Semantic proximity Read ↗

Strategies to overcome resistance to targeted protein kinase inhibitorsSemantic proximity Read ↗

The kinome 'at large' in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.