Article
A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction.
Aging cell - 1 Apr 2010
Kovalenko Olga A, Caron Matthieu J, Ulema Perihan, Medrano Carolina, Thomas Andrew P, Kimura Masayuki, Bonini Marcelo G, Herbig Utz, Santos Janine H
Abstract excerpt
Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres, but many reports show that the catalytic component of telomerase (in humans called hTERT) also localizes outside of the nucleus, including in mitochondria. Shuttling of hTERT between nucleus and cytoplasm and vice versa has been reported, and different proteins shown to regulate...
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