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Mitochondrial Trafficking and Processing of Telomerase RNA TERC

1 Sept 2018

Abstract excerpt

Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial stresses are relayed to downstream responses remains unclear. Here we show that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. We found that the import is regulated by PNPASE, and the processing is controlled by...

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Share to ATP Synthase and ATPases Research
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Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 30184494
DOI: 10.1016/j.celrep.2018.08.003

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