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Article

Live cell fluorescence resonance energy transfer predicts an altered molecular association of heterologous PrPSc with PrPC.

The Journal of biological chemistry - 19 Mar 2010

Mallik Suparna, Yang Wenbin, Norstrom Eric M, Mastrianni James A

Abstract excerpt

Prion diseases result from the accumulation of a misfolded isoform (PrP(Sc)) of the normal host prion protein (PrP(C)). PrP(Sc) propagates by templating its conformation onto resident PrP(C) to generate new PrP(Sc). Although the nature of the PrP(Sc)-PrP(C) complex is unresolved, certain segments...

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Identifiers

PMID: 20086009
DOI: 10.1074/jbc.M109.058107
PMCID: PMC2838318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20086009-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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