Article
Common genetic variants and risk for HPV persistence and progression to cervical cancer.
PloS one - 13 Jan 2010
Wang Sophia S, Gonzalez Paula, Yu Kai, Porras Carolina, Li Qizhai, Safaeian Mahboobeh, Rodriguez Ana Cecilia, Sherman Mark E, Bratti Concepcion, Schiffman Mark, Wacholder Sholom, Burk Robert D, Herrero Rolando, Chanock Stephen J, Hildesheim Allan
Abstract excerpt
HPV infrequently persists and progresses to cervical cancer. We examined host genetic factors hypothesized to play a role in determining which subset of individuals infected with oncogenic human papillomavirus (HPV) have persistent infection and further develop cervical pre-cancer/cancer compared to the majority of infected individuals who will clear infection.We evaluated 7140 tag single nucleotide polymorphisms...
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