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Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion

13 Jan 2010

Abstract excerpt

Plasmodium falciparum can invade erythrocytes by redundant receptors, some of which have variable expression. A P. falciparum clone Dd2 requiring erythrocyte sialic acid for invasion can be switched to a sialic acid-independent progeny clone Dd2NM by growing the Dd2 clone with neuraminidase-treated erythrocytes. The RH4 gene is transcriptionally up-regulated in Dd2NM compared to Dd2, despite the absence of DNA...

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PMID: 20080673
DOI: 10.1073/pnas.0913396107

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