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Article

Effect of var gene disruption on switching in Plasmodium falciparum.

Molecular microbiology - 1 Aug 2002

Horrocks Paul, Pinches Robert, Kyes Sue, Kriek Neline, Lee Sarah, Christodoulou Zóe, Newbold Chris I

Abstract excerpt

The molecular mechanisms underpinning switching of variant antigens on the surface of Plasmodium falciparum-infected erythrocytes are poorly understood. We tested the hypothesis that insertional disruption of the A4var gene, one of two var genes located within the subtelomeric region of one end of chromosome 13, would result in a preferential switch in transcription to the adjacent R29var gene upon rosette...

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PMID: 12180930
DOI: 10.1046/j.1365-2958.2002.03085.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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