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Article

Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells.

PloS one - 1 Jan 2013

Hesse Jill E, Liu Liwen, Innes Cynthia L, Cui Yuxia, Palii Stela S, Paules Richard S

Abstract excerpt

Deficiencies in the ATM gene are the underlying cause for ataxia telangiectasia, a syndrome characterized by neurological, motor and immunological defects, and a predisposition to cancer. MicroRNAs (miRNAs) are useful tools for cancer profiling and prediction of therapeutic responses to clinical regimens. We investigated the consequences of ATM deficiency on miRNA expression and associated gene expression in...

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Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial Cells

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Share to High-Throughput Nucleotide Sequencing

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Source

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Identifiers

PMID: 23741392
DOI: 10.1371/journal.pone.0064779
PMCID: PMC3669333

Genes

ATM
MAF
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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