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Article

Evaluating Many Treatments and Biomarkers in Oncology: A New Design

19 Nov 2013

Abstract excerpt

There is a pressing need for more-efficient trial designs for biomarker-stratified clinical trials. We suggest a new approach to trial design that links novel treatment evaluation with the concurrent evaluation of a biomarker within a confirmatory phase II/III trial setting. We describe a new protocol using this approach in advanced colorectal cancer called FOCUS4. The protocol will ultimately answer three...

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Share to Cancer Genomics and Diagnostics
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24248692
DOI: 10.1200/jco.2013.50.7905

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