Article
Clinical trial designs for prospective validation of biomarkers.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2005
Mandrekar Sumithra J, Grothey Axel, Goetz Matthew P, Sargent Daniel J
Abstract excerpt
Traditionally, anatomic staging systems have been used to determine predictions of individual patient outcome and, to a lesser extent, guide the choice of treatment in patients with cancer. With new targeted therapies, the role of biomarkers is increasingly promising, suggesting an integrated approach using the genetic make-up of the tumor and the genotype of the patient for treatment selection and patient...
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