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The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities

4 Jan 2017

Abstract excerpt

Hepatitis C virus (HCV)-induced hepatic stress is associated with increased oxidative DNA damage and has been implicated in hepatic inflammation. However, HCV infection and replication are uneven and vary among individual hepatocytes. To investigate the effect of the viral load on host DNA damage, we used an Enhanced Yellow Fluorescent Protein gene (EYFP)-tagged HCV virus to distinguish between HCV intracellular...

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PMID: 28052067
DOI: 10.1371/journal.pone.0164281

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