Article
Pancreatic hepatocytes. An in vivo model for cell lineage in pancreas of adult rat.
Digestive diseases and sciences - 1 Apr 1991
Reddy J K, Rao M S, Yeldandi A V, Tan X D, Dwivedi R S
Abstract excerpt
Multiple foci of hepatocytes differentiate in the pancreas of adult rats subjected to a copper depletion-repletion regimen. Copper deficiency for seven to nine weeks causes an irreversible depletion of over 80% of the acinar cells in the pancreas. When transferred to a normal diet, these rats exhibit only a minimal and spotty acinar cell recovery. This disruption of tissue organization appears to trigger a...
Topics
- Animals
- Cell Differentiation
- Copper
- Gene Expression
- Liver
- Pancreas
- Phenotype
- RNA, Messenger
- Rats
- Stem Cells