Article
Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta.
Hepatology (Baltimore, Md.) - 1 Sept 2007
Meivar-Levy Irit, Sapir Tamar, Gefen-Halevi Shiraz, Aviv Vered, Barshack Iris, Onaca Nicholas, Mor Eytan, Ferber Sarah
Abstract excerpt
UNLABELLED: It is believed that adult tissues in mammals lack the plasticity needed to assume new developmental fates because of the absence of efficient pathways of dedifferentiation. However, the well-documented ability of the transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) to activate pancreatic lineage development and insulin production following ectopic expression in liver suggests a...
Topics
- Adult
- Biomarkers
- CCAAT-Enhancer-Binding Protein-beta
- Cell Differentiation
- Cell Lineage
- Child, Preschool
- Duodenum
- Female
- Genes, Homeobox
- Homeodomain Proteins
- Humans
- Liver
- Male
- Pancreas