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Article

Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta.

Hepatology (Baltimore, Md.) - 1 Sept 2007

Meivar-Levy Irit, Sapir Tamar, Gefen-Halevi Shiraz, Aviv Vered, Barshack Iris, Onaca Nicholas, Mor Eytan, Ferber Sarah

Abstract excerpt

UNLABELLED: It is believed that adult tissues in mammals lack the plasticity needed to assume new developmental fates because of the absence of efficient pathways of dedifferentiation. However, the well-documented ability of the transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) to activate pancreatic lineage development and insulin production following ectopic expression in liver suggests a...

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PMID: 17705277
DOI: 10.1002/hep.21766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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