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Article

Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2010

Syu Aoi, Ishiguro Hiroki, Inada Toshiya, Horiuchi Yasue, Tanaka Syunsuke, Ishikawa Maya, Arai Makoto, Itokawa Masanari, Niizato Kazuhiro, Iritani Shuji, Ozaki Norio, Takahashi Makoto, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Keino-Masu Kazuko, Arikawa-Hirasawa Eri, Arinami Tadao

Abstract excerpt

Tardive dyskinesia (TD) is characterized by repetitive, involuntary, and purposeless movements that develop in patients treated with long-term dopaminergic antagonists, usually antipsychotics. By a genome-wide association screening of TD in 50 Japanese schizophrenia patients with treatment-resistant TD and 50 Japanese schizophrenia patients without TD (non-TD group) and subsequent confirmation in independent...

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Identifiers

PMID: 20072119
DOI: 10.1038/npp.2009.220
PMCID: PMC3055411

Genes

HSPG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia.PMID 20072119Read ↗

[Genome-wide association analyses for neuroleptic-induced tardive dyskinesia].Semantic proximity Read ↗

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CHRM2 and GRIN2A polymorphisms in tardive dyskinesia and cognitive impairments in Chinese Han schizophrenia.Semantic proximity Read ↗

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Combined analysis of 635 patients confirms an age-related association of the serotonin 2A receptor gene with tardive dyskinesia and specificity for the non-orofacial subtype.Semantic proximity Read ↗

Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia.Semantic proximity Read ↗

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