Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.

Journal of medicinal chemistry - 11 Feb 2010

Carolan Ciaran G, Dillon Gerald P, Khan Denise, Ryder Sheila A, Gaynor Joanne M, Reidy Sean, Marquez Juan F, Jones Mike, Holland Valerie, Gilmer John F

Abstract excerpt

Isosorbide-2-benzyl carbamate-5-benzoate is a highly potent and selective BuChE inhibitor. Meanwhile, isosorbide-2-aspirinate-5-salicylate is a highly effective aspirin prodrug that relies on the salicylate portion to interact productively with human BuChE. By integrating the salicylate group into the carbamate design, we have produced isosorbide-2-benzyl carbamate-5-salicylate, an inhibitor of high potency (150...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anions
Share to Butyrylcholinesterase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carbamates

Share to Cholinesterase Inhibitors

Share to Inhibitory Concentration 50

Share to Intestines

Share to Microsomes, Liver

Share to Salicylates

Source

Identifiers

PMID: 20067290
DOI: 10.1021/jm9014845

Genes

CES2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.PMID 20067290Read ↗

Probing the peripheral site of human butyrylcholinesterase.Semantic proximity Read ↗

Tunable nucleofugality in carbamoyl-bearing covalent cholinesterase inhibitorsSemantic proximity Read ↗

A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin.Semantic proximity Read ↗

Molecular dissection of cholinesterase domains responsible for carbamate toxicity.Semantic proximity Read ↗

Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.Semantic proximity Read ↗

Engineered hydrophobic pocket of (S)-selective arylmalonate decarboxylase variant by simultaneous saturation mutagenesis to improve catalytic performance.Semantic proximity Read ↗

Butyrylcholinesterase and G116H, G116S, G117H, G117N, E197Q and G117H/E197Q mutants: a molecular dynamics study.Semantic proximity Read ↗

Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase.Semantic proximity Read ↗

In silico studies on the role of mutant Y337A to reactivate tabun inhibited mAChE with K048.Semantic proximity Read ↗

Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE.Semantic proximity Read ↗

Converting human carbonic anhydrase II into a benzoate ester hydrolase through rational redesign.Semantic proximity Read ↗

State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.