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Article

Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.

Journal of medicinal chemistry - 11 Feb 2010

Carolan Ciaran G, Dillon Gerald P, Khan Denise, Ryder Sheila A, Gaynor Joanne M, Reidy Sean, Marquez Juan F, Jones Mike, Holland Valerie, Gilmer John F

Abstract excerpt

Isosorbide-2-benzyl carbamate-5-benzoate is a highly potent and selective BuChE inhibitor. Meanwhile, isosorbide-2-aspirinate-5-salicylate is a highly effective aspirin prodrug that relies on the salicylate portion to interact productively with human BuChE. By integrating the salicylate group int...

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Source

Identifiers

PMID: 20067290
DOI: 10.1021/jm9014845

Genes

CES2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20067290-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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