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Immature and mature megakaryocytes enhance osteoblast proliferation and inhibit osteoclast formation

5 Jan 2010

Abstract excerpt

Recent data suggest that megakaryocytes (MKs) play a role in skeletal homeostasis. In vitro and in vivo data show that MKs stimulate osteoblast (OB) proliferation and inhibit osteoclast (OC) formation, thus favoring net bone deposition. There are several mouse models with dysregulated megakaryopoiesis and resultant high bone mass phenotypes. One such model that our group has extensively studied is GATA-1...

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PMID: 20052670
DOI: 10.1002/jcb.22456

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