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Article

Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.

PloS one - 31 Dec 2009

Quinn Bridget A, Brake Tiffany, Hua Xiang, Baxter-Jones Kimberly, Litwin Samuel, Ellenson Lora Hedrick, Connolly Denise C

Abstract excerpt

BACKGROUND: Approximately one out of every ten cases of epithelial ovarian cancer (EOC) is inherited. The majority of inherited cases of EOC result from mutations in the breast cancer associated gene 1 (BRCA1). In addition to mutation of BRCA1, mutation of the p53 gene is often found in patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20046879
DOI: 10.1371/journal.pone.0008404
PMCID: PMC2796165

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20046879-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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