Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased frequency of the null allele at the complement C4b locus in autism.

Clinical and experimental immunology - 1 Mar 1991

Warren R P, Singh V K, Cole P, Odell J D, Pingree C B, Warren W L, White E

Abstract excerpt

Associations between C4 deficiency and autoimmune disorders have been found over the past several years. Since autism has several autoimmune features, the frequencies of null (no protein produced) alleles at the C4A and C4B loci were studied in 19 subjects with autism and their family members. Th...

Topics

Alleles
Autistic Disorder
Child
Complement C4a
Complement C4b
Female
Gene Frequency
Haplotypes
Humans
Male

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2004485
DOI: 10.1111/j.1365-2249.1991.tb05657.x
PMCID: PMC1535320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2004485-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased frequency of the null allele at the complement C4b locus in autism.PMID 2004485Read ↗

The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children.Semantic proximity Read ↗

Confirmation of the association of the C4B null allelle in autism.Semantic proximity Read ↗

Decreased plasma concentrations of the C4B complement protein in autism.Semantic proximity Read ↗

C4B null alleles are not associated with genetic polymorphisms in the adjacent gene CYP21A2 in autism.Semantic proximity Read ↗

Possible association of the extended MHC haplotype B44-SC30-DR4 with autism.Semantic proximity Read ↗

Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus.Semantic proximity Read ↗

Influence of C4 null alleles on C4 activation in systemic lupus erythematosus.Semantic proximity Read ↗

High frequency of C4 "null" alleles in primary antiphospholipid syndrome.Semantic proximity Read ↗

High frequencies of B8, DR3 and C4A null alleles and immunological disorders in a family of four generations.Semantic proximity Read ↗

C4 null alleles in a Swedish population.Semantic proximity Read ↗

Molecular characterisation of C4 null alleles found in Felty's syndrome.Semantic proximity Read ↗

Effects of C4 null alleles and homoduplications on quantitative expression of C4A and C4B.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.