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Article

The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion.

Breast cancer research and treatment - 1 Nov 2010

Kim Eun-Sook, Jeong Jae-Boon, Kim Seonhoe, Lee Kyung-Min, Ko Eunyoung, Noh Dong-Young, Hwang Ki-Tae, Ha Ji Hee, Lee Chang Ho, Kim Sang Geon, Moon Aree

Abstract excerpt

Although mounting evidence suggests a role for G(12) proteins, G(α12) and G(α13), in tumor progression, a direct role of G(12) proteins has not been determined. This study aims to elucidate the molecular mechanism for a tumorigenic and invasive potential of G(α12) and G(α13) in MCF10A human breast epithelial cells. Here, we report, for the first time, that G(α12) and G(α13) induce upregulation of matrix...

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Share to GTP-Binding Protein alpha Subunits, G12-G13

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to p38 Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 20044778
DOI: 10.1007/s10549-009-0697-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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