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Functional genomic analysis of glioblastoma multiforme through short interfering RNA screening: a paradigm for therapeutic development

31 Dec 2009

Abstract excerpt

Glioblastoma multiforme (GBM) is a high-grade brain malignancy arising from astrocytes. Despite aggressive surgical approaches, optimized radiation therapy regimens, and the application of cytotoxic chemotherapies, the median survival of patients with GBM from time of diagnosis remains less than 15 months, having changed little in decades. Approaches that target genes and biological pathways responsible for...

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Identifiers

PMID: 20043719
DOI: 10.3171/2009.10.focus09210

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