Article

A rare ORAI1 missense variant associates with risk of vascular diseases in White British adults

2024-03-22

Abstract excerpt

<h4>Background</h4> Pathological remodelling of native vascular smooth muscle cells (VSMC) within the arterial wall is a key contributor to vascular disease. A driver of this remodelling is platelet-derived growth factor BB (PDGF-BB) and its signalling via activation of the calcium ion channel, ORAI1. Here, we investigated if there are associations of ORAI1 polymorphisms with human cardiovascular disease. <h4>Meth...

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Literature Corpus work: f61e18ad-f543-52cf-8369-6a63f42ad6ea
DOI: 10.1101/2024.03.20.24304648

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