Article
Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease.
Basic research in cardiology - 1 Nov 2013
Fedele Francesco, Mancone Massimo, Chilian William M, Severino Paolo, Canali Emanuele, Logan Suzanna, De Marchis Maria Laura, Volterrani Maurizio, Palmirotta Raffaele, Guadagni Fiorella
Abstract excerpt
Conventionally, ischemic heart disease (IHD) is equated with large vessel coronary disease. However, recent evidence has suggested a role of compromised microvascular regulation in the etiology of IHD. Because regulation of coronary blood flow likely involves activity of specific ion channels, and key factors involved in endothelium-dependent dilation, we proposed that genetic anomalies of ion channels or...
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