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Article

STAT-phosphorylation-independent induction of interferon regulatory factor-9 by interferon-beta.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 2010

Rani M R Sandhya, Croze Ed, Wei Tao, Shrock Jennifer, Josyula Anupama, Kalvakolanu Dhananjaya V, Ransohoff Richard M

Abstract excerpt

Type I interferon (IFN)-dependent STAT1 and STAT2 activation requires specific tyrosine residues (337Y and 512Y) located in the cytoplasmic domain of IFNAR-2c, the beta-subunit of the human type I IFN receptor. To identify STAT activation-independent induction of ISGs, we used a mutant cell line in which both 337Y and 512Y were substituted with phenylalanine (337F512F or FF mutant). In these cells, type I IFN...

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Source

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Identifiers

PMID: 20038197
DOI: 10.1089/jir.2009.0032
PMCID: PMC3096491

Genes

STAT1
STAT2
EBP
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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