Article
Epstein-Barr virus DNase (BGLF5) induces genomic instability in human epithelial cells.
Nucleic acids research - 1 Apr 2010
Wu Chung-Chun, Liu Ming-Tsan, Chang Yu-Ting, Fang Chih-Yeu, Chou Sheng-Ping, Liao Hsin-Wei, Kuo Kuan-Lin, Hsu Shih-Lung, Chen Yi-Ren, Wang Pei-Wen, Chen Yu-Lian, Chuang Hsin-Ying, Lee Chia-Huei, Chen Ming, Wayne Chang Wun-Shaing, Chen Jen-Yang
Abstract excerpt
Epstein-Barr Virus (EBV) DNase (BGLF5) is an alkaline nuclease and has been suggested to be important in the viral life cycle. However, its effect on host cells remains unknown. Serological and histopathological studies implied that EBV DNase seems to be correlated with carcinogenesis. Therefore, we investigate the effect of EBV DNase on epithelial cells. Here, we report that expression of EBV DNase induces...
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