Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The DNase of Gammaherpesviruses Impairs Recognition by Virus-Specific CD8+T Cells through an Additional Host Shutoff Function

20 Dec 2007

Abstract excerpt

The DNase/alkaline exonuclease (AE) genes are well conserved in all herpesvirus families, but recent studies have shown that the AE proteins of gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) exhibit an additional function which shuts down host protein synthesis. One correlate of this additional shutoff function is that levels of cell surface HLA molecules...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18094150
DOI: 10.1128/jvi.01946-07

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

The DNase of Gammaherpesviruses Impairs Recognition by Virus-Specific CD8+T Cells through an Additional Host Shutoff FunctionPMID 18094150Read ↗

Epstein-Barr virus DNase (BGLF5) induces genomic instability in human epithelial cells.Semantic proximity Read ↗

DNA processing by the Kaposi’s sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion productionSemantic proximity Read ↗

Host Shutoff Is a Conserved Phenotype of Gammaherpesvirus Infection and Is Orchestrated Exclusively from the CytoplasmSemantic proximity Read ↗

The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.Semantic proximity Read ↗

The Epstein-Barr virus alkaline exonuclease BGLF5 serves pleiotropic functions in virus replication.Semantic proximity Read ↗

Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosisSemantic proximity Read ↗

NKp46 Recognizes the Sigma1 Protein of Reovirus: Implications for Reovirus-Based Cancer TherapySemantic proximity Read ↗

In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing EndonucleaseSemantic proximity Read ↗

Downregulation of Major Histocompatibility Complex Class I Molecules by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 ProteinsSemantic proximity Read ↗

The MHC Class I Homolog of Human Cytomegalovirus Is Resistant to Down-Regulation Mediated by the Unique Short Region Protein (US)2, US3, US6, and US11 Gene ProductsSemantic proximity Read ↗

Possible contribution of DNase gamma to immunoglobulin V gene diversification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.