Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Epstein-Barr virus alkaline exonuclease BGLF5 serves pleiotropic functions in virus replication.

Journal of virology - 1 May 2009

Feederle R, Bannert H, Lips H, Müller-Lantzsch N, Delecluse H-J

Abstract excerpt

The Epstein-Barr virus (EBV) alkaline exonuclease BGLF5 has previously been recognized to contribute to immune evasion by downregulating production of HLA molecules during virus replication. We have constructed a BGLF5-null virus mutant to determine BGLF5's functions during EBV viral replication. Quantification of virus production in permissive 293 cells carrying a DeltaBGLF5 genome identified a 17- to 21-fold...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Transformed
Share to Deoxyribonucleases
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Genetic Complementation Test

Share to Herpesvirus 4, Human

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 19264771
DOI: 10.1128/JVI.00170-09
PMCID: PMC2682060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Epstein-Barr virus alkaline exonuclease BGLF5 serves pleiotropic functions in virus replication.PMID 19264771Read ↗

The Epstein-Barr virus protein kinase BGLF4 and the exonuclease BGLF5 have opposite effects on the regulation of viral protein production.Semantic proximity Read ↗

Epstein-Barr Virus BALF3 Has Nuclease Activity and Mediates Mature Virion Production during the Lytic CycleSemantic proximity Read ↗

RNAs in Epstein–Barr virions control early steps of infectionSemantic proximity Read ↗

EBV Lytic-Phase Protein BGLF5 Contributes to TLR9 Downregulation during Productive InfectionSemantic proximity Read ↗

Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production.Semantic proximity Read ↗

Systematic analysis of Epstein-Barr virus genes and their individual contribution to virus production and compositionSemantic proximity Read ↗

Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanismsSemantic proximity Read ↗

Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5Semantic proximity Read ↗

Primary B-cell infection with a deltaBALF4 Epstein-Barr virus comes to a halt in the endosomal compartment yet still elicits a potent CD4-positive cytotoxic T-cell response.Semantic proximity Read ↗

Micro RNAs of Epstein-Barr Virus Promote Cell Cycle Progression and Prevent Apoptosis of Primary Human B CellsSemantic proximity Read ↗

Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartmentsSemantic proximity Read ↗

Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.