Epigenetic Silence of Ankyrin-Repeat–Containing, Sh3-Domain–Containing, and Proline-Rich-Region– Containing Protein 1 ( Aspp1 ) and Aspp2 Genes Promotes Tumor Growth in Hepatitis B Virus–Positive Hepatocellular Carcinoma

Abstract excerpt

UNLABELLED: The ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein (ASPP) family of proteins regulates apoptosis through interaction with p53 and its family members. This study evaluated the epigenetic regulation of ASPP1 and ASPP2 in hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC) and explores the effects of down-regulation of ASPP1 and ASPP2 on the...

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