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Article

Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.

Gastroenterology - 1 Oct 2011

Huang Yuehua, Tong Shuping, Tai Andrew W, Hussain Munira, Lok Anna S F

Abstract excerpt

BACKGROUND & AIMS: Clinical studies have associated hepatitis B virus core promoter (CP) mutations with an increased risk of hepatocellular carcinoma. The CP region overlaps with the HBV X (HBx) gene, which has been implicated in hepatocarcinogenesis. The cyclin kinase inhibitor p21WAF1/CIP1 is a...

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Share to Cell Transformation, Viral
Share to Cyclin-Dependent Kinase Inhibitor p21
Share to Hep G2 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proteasome Endopeptidase Complex

Share to S-Phase Kinase-Associated Proteins

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Source

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Identifiers

PMID: 21704589
DOI: 10.1053/j.gastro.2011.06.048
PMCID: PMC3186859

Genes

SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21704589-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.PMID 21704589Read ↗

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