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Epigenetic Dysregulation of the Expression of PRSS3 Splice Variants Increases the Heterogeneity of Transcripts and Functionality in Human Hepatocellular Carcinoma

2021-09-09

Abstract excerpt

<title>Abstract</title> <p>Background Hepatocellular carcinoma (HCC) is one of the most lethal human tumors with extensive heterogeneity. Serine protease 3 (PRSS3) is an indispensable member of the trypsin family and has been implicated in the pathogenesis of several malignancies including HCC. However, paradoxical effects of <italic>PPRSS3</italic> on carcinogenesis impede the utilization of its biomarker poten...

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Literature Corpus work
d7e283c1-66c4-5e73-a49c-3feafda871df
DOI
10.21203/rs.3.rs-861068/v1
Open publication

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