Article
SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome.
Circulation. Cardiovascular genetics - 1 Dec 2009
Probst Vincent, Wilde Arthur A M, Barc Julien, Sacher Frederic, Babuty Dominique, Mabo Philippe, Mansourati Jacques, Le Scouarnec Solena, Kyndt Florence, Le Caignec Cedric, Guicheney Pascale, Gouas Laetitia, Albuisson Juliette, Meregalli Paola G, Le Marec Hervé, Tan Hanno L, Schott Jean-Jacques
Abstract excerpt
BACKGROUND: Mutations in SCN5A are identified in approximately 20% to 30% of probands affected by Brugada syndrome (BrS). However, in familial studies, the relationship between SCN5A mutations and BrS remains poorly understood. The aim of this study was to investigate the association of SCN5A mut...
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