Brugada syndrome genetics is associated with phenotype severity.

doi:10.1093/eurheartj/ehaa942

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Article

Brugada syndrome genetics is associated with phenotype severity.

European heart journal - 14 Mar 2021

Ciconte Giuseppe, Monasky Michelle M, Santinelli Vincenzo, Micaglio Emanuele, Vicedomini Gabriele, Anastasia Luigi, Negro Gabriele, Borrelli Valeria, Giannelli Luigi, Santini Francesca, de Innocentiis Carlo, Rondine Roberto, Locati Emanuela T, Bernardini Andrea, Mazza Beniamino C, Mecarocci Valerio, Ćalović Žarko, Ghiroldi Andrea, D'Imperio Sara, Benedetti Sara, Di Resta Chiara, Rivolta Ilaria, Casari Giorgio, Petretto Enrico, Pappone Carlo

Abstract excerpt

AIMS: Brugada syndrome (BrS) is associated with an increased risk of sudden cardiac death due to ventricular tachycardia/fibrillation (VT/VF) in young, otherwise healthy individuals. Despite SCN5A being the most commonly known mutated gene to date, the genotype-phenotype relationship is poorly understood and remains uncertain. This study aimed to elucidate the genotype-phenotype correlation in BrS. METHODS AND...

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Identifiers

PMID: 33221895
DOI: 10.1093/eurheartj/ehaa942
PMCID: PMC7955973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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