Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure.

doi:10.1592/phco.30.1.1

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Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure.

Pharmacotherapy - 1 Jan 2010

Cavallari Larisa H, Groo Vicki L, Viana Marlos A G, Dai Yang, Patel Shitalben R, Stamos Thomas D

Abstract excerpt

STUDY OBJECTIVE: To identify patient-specific factors associated with spironolactone-induced potassium level elevation in patients with heart failure. DESIGN: Prospective cohort study. SETTING: Two adult heart failure clinics. PATIENTS: Sixty-two adult (mean +/- SD age 54 +/- 16 yrs) aldosterone antagonist-naïve patients with heart failure. INTERVENTION: Patients received spironolactone 12.5 mg/day, titrated to...

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Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure.

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