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Article

[Exploration of pathogenesis and therapy development for ALS employing sporadic disease model].

Rinsho shinkeigaku = Clinical neurology - 1 Nov 2009

Tanaka Fumiaki, Waza Masahiro, Yamamoto Masahiko, Sobue Gen

Abstract excerpt

The mechanisms underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remain poorly understood even now 140 years after the first description of the disease in 1869 by Jean-Martin Charcot. Exploration of pathogenesis of ALS has long been dependent on transgenic animal models with mutations in the copper/ zinc superoxide dismutase 1 (SOD1) gene. However, the lack of therapeutic concordance...

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Source

Identifiers

PMID: 20030217
DOI: 10.5692/clinicalneurol.49.811

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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