[Familial amyotrophic lateral sclerosis and mutations in the Cu/Zn superoxide dismutase gene].

Article

[Familial amyotrophic lateral sclerosis and mutations in the Cu/Zn superoxide dismutase gene].

Rinsho shinkeigaku = Clinical neurology - 1 Dec 1995

Nakano R

Abstract excerpt

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder affecting primarily upper and lower motor neurons. In all cases of ALS, approximately 5-10% of cases are familial (FALS). Missense mutations in the Cu/Zn superoxide dismutase (SOD1) gene on chromosome 21 have been demonstrated in...

Topics

Amyotrophic Lateral Sclerosis
Animals
Chromosomes, Human, Pair 21
Free Radicals
Humans
Mice
Mice, Transgenic
Motor Neurons
Mutation
Nerve Degeneration
Superoxide Dismutase

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