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Article

In Vitro Models of Amyotrophic Lateral Sclerosis.

Cellular and molecular neurobiology - 1 Nov 2023

Zhou Lijun, Chen Wenzhi, Jiang Shishi, Xu Renshi

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is one of the commonest neurodegenerative diseases of adult-onset, which is characterized by the progressive death of motor neurons in the cerebral cortex, brain stem and spinal cord. The dysfunction and death of motor neurons lead to the progressive muscle weakness, atrophy, fasciculations, spasticity and ultimately the whole paralysis of body. Despite the identification of...

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PMID: 37870685
DOI: 10.1007/s10571-023-01423-8

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