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Article

Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors.

Neuropharmacology - 1 Jan 2009

Plested Andrew J R, Mayer Mark L

Abstract excerpt

Kainate receptors are allosterically regulated by sodium ions. Removal of Na+ from the extracellular solution, or replacement of Na+ by larger monovalent cations, inhibits kainate receptor activity. Sodium binds at a negatively charged cavity in the extracellular neurotransmitter binding domain that is capped by a small hydrophobic residue. Prior work revealed that introduction of aspartic acid at this site...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18687343
DOI: 10.1016/j.neuropharm.2008.07.013
PMCID: PMC2629458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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