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Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines

1 Apr 2011

Abstract excerpt

DNA methylation is involved in development and in human diseases. Genomic DNA derived from lymphoblastoid cell lines (LCLs) is commonly used to study DNA methylation. There are potential confounding factors regarding the use of LCL-derived DNA, however, such as Epstein-Barr (EB) viral infection and artifacts induced during cell culture. Recently, several groups compared the DNA methylation status of peripheral...

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PMID: 21304276
DOI: 10.4161/epi.6.4.14876

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