Article
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
Blood - 4 Mar 2010
Solovieff Nadia, Milton Jacqueline N, Hartley Stephen W, Sherva Richard, Sebastiani Paola, Dworkis Daniel A, Klings Elizabeth S, Farrer Lindsay A, Garrett Melanie E, Ashley-Koch Allison, Telen Marilyn J, Fucharoen Supan, Ha Shau Yin, Li Chi-Kong, Chui David H K, Baldwin Clinton T, Steinberg Martin H
Abstract excerpt
In a genome-wide association study of 848 blacks with sickle cell anemia, we identified single nucleotide polymorphisms (SNPs) associated with fetal hemoglobin concentration. The most significant SNPs in a discovery sample were tested in a replication set of 305 blacks with sickle cell anemia and in subjects with hemoglobin E or beta thalassemia trait from Thailand and Hong Kong. A novel region on chromosome 11...
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