Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the minimal functional unit of the homo-oligomeric human reduced folate carrier.

The Journal of biological chemistry - 12 Feb 2010

Hou Zhanjun, Cherian Christina, Drews Joseph, Wu Jianmei, Matherly Larry H

Abstract excerpt

The reduced folate carrier (RFC) is the major transport system for folates in mammals. We previously demonstrated the existence of human RFC (hRFC) homo-oligomers and established the importance of these higher order structures to intracellular trafficking and carrier function. In this report, we examined the operational significance of hRFC oligomerization and the minimal functional unit for transport. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electrophoresis, Polyacrylamide Gel
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Membrane Transport Proteins

Share to Mesylates

Share to Microscopy, Confocal

Share to Protein Multimerization

Share to Reduced Folate Carrier Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20018840
DOI: 10.1074/jbc.M109.086033
PMCID: PMC2836078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the minimal functional unit of the homo-oligomeric human reduced folate carrier.PMID 20018840Read ↗

Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates.Semantic proximity Read ↗

Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods.Semantic proximity Read ↗

Folate transporter dynamics and therapy with classic and tumor-targeted antifolatesSemantic proximity Read ↗

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognitionSemantic proximity Read ↗

Reduced folate carrier: biochemistry and molecular biology of the normal and methotrexate-resistant cell.Semantic proximity Read ↗

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.Semantic proximity Read ↗

A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate.Semantic proximity Read ↗

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.Semantic proximity Read ↗

The human proton-coupled folate transporterSemantic proximity Read ↗

Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers.Semantic proximity Read ↗

Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.Semantic proximity Read ↗

Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal trancriptional regulatory region in an antifolate-resistant HeLa cell lineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.