Genetic background of Richter transformation of atypical chronic lymphocytic leukemia to diffuse large B-cell lymphoma - a case study.

doi:10.1007/s13353-025-00999-9

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Article

Genetic background of Richter transformation of atypical chronic lymphocytic leukemia to diffuse large B-cell lymphoma - a case study.

Journal of applied genetics - 1 Sept 2026

Przybysz Sandra, Łojko-Dankowska Anna, Rakoczy Magdalena, Marcinkowska-Swojak Małgorzata, Zeńczak Michał, Gwóźdź-Bąk Kinga, Handschuh Luiza, Lewandowski Krzysztof

Abstract excerpt

Atypical chronic lymphocytic leukemia (aCLL) is an indolent lymphoproliferative neoplasm derived from CD19-positive and CD5 or CD23-negative B cells. This paper presents the results of whole genome sequencing (WGS) of lymphoma cells collected from a 29-year-old woman initially diagnosed with aCLL and successfully treated with fludarabine, cyclophosphamide, and rituximab. Eight years later, due to disease...

Read the complete abstract on PubMed

Topics

Humans
Lymphoma, Large B-Cell, Diffuse
Female
Leukemia, Lymphocytic, Chronic, B-Cell
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Transformation, Neoplastic

Whole Genome Sequencing

Rituximab

Cyclophosphamide

Mutation

Adenine

Piperidines

Source

Open in PubMed Open full text

Identifiers

PMID: 40782136
DOI: 10.1007/s13353-025-00999-9
PMCID: PMC13534210

Genes

ZMYM3
ALG6
ATG7
CD19
CD5
COL11A1
MGME1
UBA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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