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Article

Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia.

Endocrinology - 1 Dec 2017

Eachus Helen, Zaucker Andreas, Oakes James A, Griffin Aliesha, Weger Meltem, Güran Tülay, Taylor Angela, Harris Abigail, Greenfield Andy, Quanson Jonathan L, Storbeck Karl-Heinz, Cunliffe Vincent T, Müller Ferenc, Krone Nils

Abstract excerpt

Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis due to severe 21OHD remains poorly understood. Therefore, we developed a zebrafish model for 21OHD, which focuses on the impairment of glucocorticoid biosynthesis. A single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28938470
DOI: 10.1210/en.2017-00549
PMCID: PMC5711382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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